Shelby
12-18-2005, 09:51 AM
Baclofen as a Cocaine Anti-Craving Medication: A Preliminary Clinical Study
The lack of success in finding an effective pharmacological treatment for cocaine abuse may, in part, be due to the drug's apparent action on multiple and specific neurotransmitter systems, as well as the episodic nature of cocaine itself. Cocaine craving is frequently cueinduced, and appears to be accompanied by increases in dopamine and noradrenaline release, as well as cortical arousal and increased metabolism in the frontal cortex, induced by catecholamines and probably also glutamate.
http://origin.www.nature.com/npp/journal/v18/n5/full/1395109a.html (http://www.nature.com/npp/journal/v18/n5/full/1395109a.html)
The lack of success in finding an effective pharmacological treatment for cocaine abuse may, in part, be due to the drug's apparent action on multiple and specific neurotransmitter systems, as well as the episodic nature of cocaine itself. Cocaine craving is frequently cueinduced, and appears to be accompanied by increases in dopamine and noradrenaline release, as well as cortical arousal and increased metabolism in the frontal cortex, induced by catecholamines and probably also glutamate.
http://origin.www.nature.com/npp/journal/v18/n5/full/1395109a.html (http://www.nature.com/npp/journal/v18/n5/full/1395109a.html)